Protein name:
Slit homolog 2 protein (Slit-2) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Interacts with GREM1 (By similarity). Binds ROBO1 and ROBO2 with high affinity.
Function:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development, may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system, appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
Subcellular Location:
Secreted
The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.
Protein Attributes:
50:
MSGIGWQTLS | LSLGLVLSIL | NKVAPQACPA | QCSCSGSTVD | CHGLALRSVP |
100:
RNIPRNTERL | DLNGNNITRI | TKIDFAGLRH | LRVLQLMENR | ISTIERGAFQ |
150:
DLKELERLRL | NRNNLQLFPE | LLFLGTAKLY | RLDLSENQIQ | AIPRKAFRGA |
200:
VDIKNLQLDY | NQISCIEDGA | FRALRDLEVL | TLNNNNITRL | SVASFNHMPK |
250:
LRTFRLHSNN | LYCDCHLAWL | SDWLRQRPRV | GLYTQCMGPS | HLRGHNVAEV |
300:
QKREFVCSGH | QSFMAPSCSV | LHCPAACTCS | NNIVDCRGKG | LTEIPTNLPE |
350:
TITEIRLEQN | SIRVIPPGAF | SPYKKLRRLD | LSNNQISELA | PDAFQGLRSL |
400:
NSLVLYGNKI | TELPKSLFEG | LFSLQLLLLN | ANKINCLRVD | AFQDLHNLNL |
450:
LSLYDNKLQT | VAKGTFSALR | AIQTMHLAQN | PFICDCHLKW | LADYLHTNPI |
500:
ETSGARCTSP | RRLANKRIGQ | IKSKKFRCSG | TEDYRSKLSG | DCFADLACPE |
550:
KCRCEGTTVD | CSNQRLNKIP | DHIPQYTAEL | RLNNNEFTVL | EATGIFKKLP |
600:
QLRKINFSNN | KITDIEEGAF | EGASGVNEIL | LTSNRLENVQ | HKMFKGLESL |
650:
KTLMLRSNRI | SCVGNDSFIG | LGSVRLLSLY | DNQITTVAPG | AFDSLHSLST |
700:
LNLLANPFNC | NCHLAWLGEW | LRRKRIVTGN | PRCQKPYFLK | EIPIQDVAIQ |
750:
DFTCDDGNDD | NSCSPLSRCP | SECTCLDTVV | RCSNKGLKVL | PKGIPKDVTE |
800:
LYLDGNQFTL | VPKELSNYKH | LTLIDLSNNR | ISTLSNQSFS | NMTQLLTLIL |
850:
SYNRLRCIPP | RTFDGLKSLR | LLSLHGNDIS | VVPEGAFNDL | SALSHLAIGA |
900:
NPLYCDCNMQ | WLSDWVKSEY | KEPGIARCAG | PGEMADKLLL | TTPSKKFTCQ |
950:
GPVDITIQAK | CNPCLSNPCK | NDGTCNNDPV | DFYRCTCPYG | FKGQDCDVPI |
1000:
HACISNPCKH | GGTCHLKEGE | NAGFWCTCAD | GFEGENCEVN | IDDCEDNDCE |
1050:
NNSTCVDGIN | NYTCLCPPEY | TGELCEEKLD | FCAQDLNPCQ | HDSKCILTPK |
1100:
GFKCDCTPGY | IGEHCDIDFD | DCQDNKCKNG | AHCTDAVNGY | TCVCPEGYSG |
1150:
LFCEFSPPMV | LPRTSPCDNF | DCQNGAQCII | RINEPICQCL | PGYLGEKCEK |
1200:
LVSVNFVNKE | SYLQIPSAKV | RPQTNITLQI | ATDEDSGILL | YKGDKDHIAV |
1250:
ELYRGRVRAS | YDTGSHPASA | IYSVETINDG | NFHIVELLTL | DSSLSLSVDG |
1300:
GSPKVITNLS | KQSTLNFDSP | LYVGGMPGKN | NVASLRQAPG | QNGTSFHGCI |
1350:
RNLYINSELQ | DFRKMPMQTG | ILPGCEPCHK | KVCAHGMCQP | SSQSGFTCEC |
1400:
EEGWMGPLCD | QRTNDPCLGN | KCVHGTCLPI | NAFSYSCKCL | EGHGGVLCDE |
1450:
EEDLFNPCQM | IKCKHGKCRL | SGVGQPYCEC | NSGFTGDSCD | REISCRGERI |
1500:
RDYYQKQQGY | AACQTTKKVS | RLECRGGCAG | GQCCGPLRSK | RRKYSFECTD |
1521:
GSSFVDEVEK | VVKCGCARCA | S
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse Slit-2
ELISA Kit for Mouse Slit-2
ELISA Kit for Mouse Slit-2
CLIA Kit for Mouse Slit-2
CLIA Kit for Mouse Slit-2
CLIA Kit for Mouse Slit-2
Polyclonal Antibody for Mouse Slit-2
Polyclonal Antibody for Mouse Slit-2
Polyclonal Antibody for Mouse Slit-2
Monoclonal Antibody for Mouse Slit-2
Monoclonal Antibody for Mouse Slit-2
Monoclonal Antibody for Mouse Slit-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE
strain :
ICR X Swiss Webster .
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 497-1521
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 577-1521
strain :
C57BL/6 .
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE